Maternal use of cyclobenzaprine Flexeril may induce ductal closure and persistent pulmonary hypertension in neonates
What to Expect has thousands of open discussions happening each day. We work hard to share our most timely and active conversations with you. Keep this and all medicines out of the reach of children. Your doctor will prescribe the appropriate dosage ofFlexeril depending on the condition being treated and your response to the medication. Alcohol may intensify some of the side effects of this medication.
Flexeril, known generically as cyclobenzaprine, is a muscle relaxant most often given for treatment of injury or muscle strain 1. If you are pregnant, tell your doctor about your condition and about all medications you are taking before taking any additional medication to make sure it is safe for you and your baby. Your doctor will decide whether Flexeril or any other medication is safe enough for you to take during pregnancy 1.
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Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease. All patients suspected of an overdose with FLEXERIL should receive gastrointestinal decontamination. This should include large volume gastric lavage followed by activated charcoal. If consciousness is impaired, the airway should be secured prior to lavage and emesis is contraindicated. In order to protect against the rare but potentially critical manifestations described above, obtain an ECG and immediately initiate cardiac monitoring.
This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and https://flexeril.live herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
The initial dose is 50 to 100 mg at bedtime that may be increased by 25 or 50 mg at bedtime as needed. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Before taking cyclobenzaprine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. If you notice other effects not listed above, contact your doctor or pharmacist. Overdose symptoms may include severe drowsiness, vomiting, fast heartbeats, tremors, agitation, or hallucinations.
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For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
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Sometimes, muscle relaxants like cyclobenzaprine are used “off-label” to treat conditions they’re not approved for, such as fibromyalgia. Therefore, nursing mothers should use cyclobenzaprine with caution (2). Used short-term to treat muscle spasms and works by helping to relax the muscles. According to the observation from the Food and Drug Administration, it was tested on rats, mice and rabbits in their pregnancy.
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Like all TCAs, amitriptyline increases levels of the neurotransmitter norepinephrine and serotonin, and blocks the action of acetylcholine, another neurotransmitter. It is believed that by restoring the balance of these different neurotransmitters in the brain that depression is alleviated. During pregnancy, this medication should be used only when clearly needed. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
- Common side effects that could occur when you take Cyclobenzaprine are dizziness and drowsiness.
- This product may contain inactive ingredients, which can cause allergic reactions or other problems.
- Although not all of these side effects may occur, if they do occur they may need medical attention.
- Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others.
The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache. Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome).
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Amitriptyline is used with caution in patients with seizures since it can increase the risk of seizures. Amitriptyline is a tricyclic antidepressant (TCA) and is used for treating depression. Other TCAs include clomipramine (Anafranil), doxepin (Sinequan), imipramine (Tofranil), trimipramine (Surmontil), amoxapine (Amoxapine), desipramine (Norpramin), and protriptyline (Vivactil). Individuals with depression may have an imbalance in neurotransmitters, chemicals that nerves make and use to communicate with other nerves.
